Magnesium for Depression and Anxiety

I’m a huge fan of magnesium. It is one of my top favorite natural solutions for anxiety and depression. It’s been said that more than 80% of people are deficient in this important mineral.

The quintessential resource on this subject is The Magnesium Miracle, by Dr. Carolyn Dean. The author recently posted a free e-book on her website entitled “Magnesium Deficient Anxiety: How to Live Anxiety-Free with Magnesium.” This free book contains a wealth of information and can be found here. I wish I could give every person who suffers from anxiety a copy of this book. It would eliminate so much suffering!


There are many scientific articles that corroborate that magnesium is a safe, effective treatment for depression and anxiety. One such article was published last week in the scientific journal PLoS One.

Role of magnesium supplementation in the treatment of depression: A randomized clinical trial  (Published online at

“Consumption of magnesium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treatments. Effects were observed within two weeks. Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”

Here’s another article supporting the above findings:

Rapid Recovery from major depression using magnesium treatment (Med Hypotheses. 2006;67(2):362-70. Epub 2006 Mar 20)

“Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use.”

Have you used magnesium to address anxiety and/or depression? Please share your experience in the comments section.

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